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Proceedings Paper

Microarchitecture of irradiated bone: comparison with healthy bone
Author(s): Pauline Bléry; Yves Amouriq; Jeanpierre Guédon; Paul Pilet; Nicolas Normand; Nicolas Durand; Florent Espitalier; Aurore Arlicot; Olivier Malard; Pierre Weiss
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Paper Abstract

The squamous cell carcinomas of the upper aero-digestive tract represent about ten percent of cancers. External radiation therapy leads to esthetic and functional consequences, and to a decrease of the bone mechanical abilities. For these patients, the oral prosthetic rehabilitation, including possibilities of dental implant placement, is difficult. The effects of radiotherapy on bone microarchitecture parameters are not well known. Thus, the purpose of this study is to assess the effects of external radiation on bone micro architecture in an experimental model of 25 rats using micro CT. 15 rats were irradiated on the hind limbs by a single dose of 20 Grays, and 10 rats were non irradiated. Images of irradiated and healthy bone were compared. Bone microarchitecture parameters (including trabecular thickness, trabecular number, trabecular separation, connectivity density and tissue and bone volume) between irradiated and non-irradiated bones were calculated and compared using a Mann and Whitney test. After 7 and 12 weeks, images of irradiated and healthy bone are different. Differences on the irradiated and the healthy bone populations exhibit a statistical significance. Trabecular number, connectivity density and closed porosity are less important on irradiated bone. Trabecular thickness and separation increase for irradiated bone. These parameters indicate a decrease of irradiated bone properties. Finally, the external irradiation induces changes on the bone micro architecture. This knowledge is of prime importance for better oral prosthetic rehabilitation, including implant placement.

Paper Details

Date Published: 16 April 2012
PDF: 12 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 831719 (16 April 2012); doi: 10.1117/12.911375
Show Author Affiliations
Pauline Bléry, Institut de Recherche en Communications et Cybernétique de Nantes, CNRS, Univ. de Nantes (France)
Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Yves Amouriq, Institut de Recherche en Communications et Cybernétique de Nantes, CNRS, Univ. de Nantes (France)
Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Jeanpierre Guédon, Institut de Recherche en Communications et Cybernétique de Nantes, CNRS, Univ. de Nantes (France)
Paul Pilet, Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Nicolas Normand, Institut de Recherche en Communications et Cybernétique de Nantes, CNRS, Univ. de Nantes (France)
Nicolas Durand, Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Florent Espitalier, Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Aurore Arlicot, Institut de Recherche en Communications et Cybernétique de Nantes, CNRS, Univ. de Nantes (France)
Olivier Malard, Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)
Pierre Weiss, Lab. d'Ingénierie Ostéo- Articulaire et Dentaire, Univ. de Nantes (France)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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