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Proceedings Paper

Breast ultrasound tomography: bridging the gap to clinical practice
Author(s): Neb Duric; Peter Littrup; Cuiping Li; Olivier Roy; Steven Schmidt; Roman Janer; Xiaoyang Cheng; Jeffrey Goll; Olsi Rama; Lisa Bey-Knight; William Greenway
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Paper Abstract

Conventional sonography, which performs well in dense breast tissue and is comfortable and radiation-free, is not practical for screening because of its operator dependence and the time needed to scan the whole breast. While magnetic resonance imaging (MRI) can significantly improve on these limitations, it is also not practical because it has long been prohibitively expensive for routine use. There is therefore a need for an alternative breast imaging method that obviates the constraints of these standard imaging modalities. The lack of such an alternative is a barrier to dramatically impacting mortality (about 45,000 women in the US per year) and morbidity from breast cancer because, currently, there is a trade-off between the cost effectiveness of mammography and sonography on the one hand and the imaging accuracy of MRI on the other. This paper presents a progress report on our long term goal to eliminate this trade-off and thereby improve breast cancer survival rates and decrease unnecessary biopsies through the introduction of safe, cost-effective, operatorindependent sonography that can rival MRI in accuracy. The objective of the study described in this paper was to design and build an improved ultrasound tomography (UST) scanner in support of our goals. To that end, we report on a design that builds on our current research prototype. The design of the new scanner is based on a comparison of the capabilities of our existing prototype and the performance needed for clinical efficacy. The performance gap was quantified by using clinical studies to establish the baseline performance of the research prototype, and using known MRI capabilities to establish the required performance. Simulation software was used to determine the basic operating characteristics of an improved scanner that would provide the necessary performance. Design elements focused on transducer geometry, which in turn drove the data acquisition system and the image reconstruction engine specifications. The feasibility of UST established by our earlier work and that of other groups, forms the rationale for developing a UST system that has the potential to become a practical, low-cost device for breast cancer screening and diagnosis.

Paper Details

Date Published: 24 February 2012
PDF: 9 pages
Proc. SPIE 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy, 83200O (24 February 2012); doi: 10.1117/12.910988
Show Author Affiliations
Neb Duric, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Peter Littrup, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Cuiping Li, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Olivier Roy, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Steven Schmidt, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Roman Janer, Karmanos Cancer Institute, Wayne State Univ. (United States)
Xiaoyang Cheng, Karmanos Cancer Institute, Wayne State Univ. (United States)
Jeffrey Goll, Karmanos Cancer Institute, Wayne State Univ. (United States)
Olsi Rama, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
Lisa Bey-Knight, Karmanos Cancer Institute, Wayne State Univ. (United States)
Delphinus Medical Technologies (United States)
William Greenway, Karmanos Cancer Institute, Wayne State Univ. (United States)


Published in SPIE Proceedings Vol. 8320:
Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy
Johan G. Bosch; Marvin M. Doyley, Editor(s)

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