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Proceedings Paper

Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors
Author(s): Jason Zalev; Don Herzog; Bryan Clingman; Tom Miller; Kenneth Kist; N. Carol Dornbluth; B. Michelle McCorvey; Pamela Otto; Sergey Ermilov; Vyacheslav Nadvoretsky; Andre Conjusteau; Richard Su; Dmitri Tsyboulski; Alexander Oraevsky
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Paper Abstract

Two-dimensional optoacoustic imaging with a hand-held probe operated in backward mode is being developed for diagnostic imaging of breast cancer to evaluate the feasibility of a dual-modality optoacoustic plus ultrasonic system that maps functional information of anatomical tissue structures with ultrasonic resolution. Tissue is illuminated at 757nm and 1064nm for optical contrast between hypoxic blood of breast carcinomas and normally oxygenated blood in benign masses. The system is optimized and calibrated in phantoms for a pilot clinical study of patients with breast masses suspected for malignancy. Capability of the non-invasive system to improve detection and diagnosis of breast tumors is discussed.

Paper Details

Date Published: 23 February 2012
PDF: 6 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230A (23 February 2012); doi: 10.1117/12.910968
Show Author Affiliations
Jason Zalev, Seno Medical Instruments, Inc. (United States)
Don Herzog, Seno Medical Instruments, Inc. (United States)
Bryan Clingman, Seno Medical Instruments, Inc. (United States)
Tom Miller, Seno Medical Instruments, Inc. (United States)
Kenneth Kist, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
N. Carol Dornbluth, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
B. Michelle McCorvey, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Pamela Otto, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Sergey Ermilov, TomoWave Labs., Inc. (United States)
Vyacheslav Nadvoretsky, TomoWave Labs., Inc. (United States)
Andre Conjusteau, TomoWave Labs., Inc. (United States)
Richard Su, TomoWave Labs., Inc. (United States)
Dmitri Tsyboulski, TomoWave Labs., Inc. (United States)
Alexander Oraevsky, TomoWave Labs., Inc. (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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