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Proceedings Paper

Computer-assisted diagnostic tool to quantify the pulmonary veins in sickle cell associated pulmonary hypertension
Author(s): Guido H. Jajamovich; Vivek Pamulapati; Shoaib Alam; Alem Mehari; Gregory J. Kato; Bradford J. Wood; Marius George Linguraru
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Paper Abstract

Pulmonary hypertension is a common cause of death among patients with sickle cell disease. This study investigates the use of pulmonary vein analysis to assist the diagnosis of pulmonary hypertension non-invasively with CT-Angiography images. The characterization of the pulmonary veins from CT presents two main challenges. Firstly, the number of pulmonary veins is unknown a priori and secondly, the contrast material is degraded when reaching the pulmonary veins, making the edges of these vessels to appear faint. Each image is first denoised and a fast marching approach is used to segment the left atrium and pulmonary veins. Afterward, a geodesic active contour is employed to isolate the left atrium. A thinning technique is then used to extract the skeleton of the atrium and the veins. The locations of the pulmonary veins ostia are determined by the intersection of the skeleton and the contour of the atrium. The diameters of the pulmonary veins are measured in each vein at fixed distances from the corresponding ostium, and for each distance, the sum of the diameters of all the veins is computed. These indicators are shown to be significantly larger in sickle-cell patients with pulmonary hypertension as compared to controls (p-values < 0.01).

Paper Details

Date Published: 16 April 2012
PDF: 6 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83171J (16 April 2012); doi: 10.1117/12.910966
Show Author Affiliations
Guido H. Jajamovich, Columbia Univ. (United States)
Vivek Pamulapati, National Institutes of Health (United States)
Shoaib Alam, National Heart Lung and Blood Institute, National Institutes of Health (United States)
Alem Mehari, National Heart Lung and Blood Institute, National Institutes of Health (United States)
Howard Univ. College of Medicine (United States)
Gregory J. Kato, National Heart Lung and Blood Institute, National Institutes of Health (United States)
Bradford J. Wood, National Heart Lung and Blood Institute, National Institutes of Health (United States)
Marius George Linguraru, National Institutes of Health (United States)
Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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