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Proceedings Paper

Automatic three-dimensional registration of intra-vascular optical coherence tomography images for the clinical evaluation of stent implantation over time
Author(s): Giovanni J. Ughi; Tom Adriaenssens; Matilda Larsson; Christophe Dubois; Peter Sinnaeve; Mark Coosemans; Walter Desmet; Jan D'hooghe
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Paper Abstract

In the last decade a large number of new intracoronary devices (i.e. drug-eluting stents, DES) have been developed to reduce the risks related to bare metal stent (BMS) implantation. The use of this new generation of DES has been shown to substantially reduce, compared with BMS, the occurrence of restenosis and recurrent ischemia that would necessitate a second revascularization procedure. Nevertheless, safety issues on the use of DES persist and full understanding of mechanisms of adverse clinical events is still a matter of concern and debate. Intravascular Optical Coherence Tomography (IV-OCT) is an imaging technique able to visualize the microstructure of blood vessels with an axial resolution <20 μm. Due to its very high spatial resolution, it enables detailed in-vivo assessment of implanted devices and vessel wall. Currently, the aim of several major clinical trials is to observe and quantify the vessel response to DES implantation over time. However, image analysis is currently performed manually and corresponding images, belonging to different IV-OCT acquisitions, can only be matched through a very labor intensive and subjective procedure. The aim of this study is to develop and validate a new methodology for the automatic registration of IV-OCT datasets on an image level. Hereto, we propose a landmark based rigid registration method exploiting the metallic stent framework as a feature. Such a tool would provide a better understanding of the behavior of different intracoronary devices in-vivo, giving unique insights about vessel pathophysiology and performance of new generation of intracoronary devices and different drugs.

Paper Details

Date Published: 30 January 2012
PDF: 11 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82132K (30 January 2012); doi: 10.1117/12.910597
Show Author Affiliations
Giovanni J. Ughi, Catholic Univ. Leuven (Belgium)
Tom Adriaenssens, Univ. Hospitals Leuven (Belgium)
Matilda Larsson, Catholic Univ. Leuven (Belgium)
Royal Institute of Technology (Sweden)
Christophe Dubois, Catholic Univ. Leuven (Belgium)
Univ. Hospitals Leuven (Belgium)
Peter Sinnaeve, Catholic Univ. Leuven (Belgium)
Univ. Hospitals Leuven (Belgium)
Mark Coosemans, Univ. Hospitals Leuven (Belgium)
Walter Desmet, Catholic Univ. Leuven (Belgium)
Univ. Hospitals Leuven (Belgium)
Jan D'hooghe, Catholic Univ. Leuven (Belgium)

Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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