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Proceedings Paper

Determination of the scattering coefficient, the reduced scattering coefficient, and the anisotropy factor of tissue with differential interference contrast microscopy
Author(s): Bianca DeAngelo; Grant Arzumanov; Patrick Shanley; Zhang Xu; M. Xu
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Paper Abstract

We report an approach for determination of the scattering coefficient, the reduced scattering coefficient, and the anisotropy factor from the quantitative phase map measured by differential interference contrast microscopy based on the scatteringphase theorem. The approach is first validated by showing the excellent agreement between the retrieved optical properties of polystyrene spheres and Intralipid-20% suspension and their known values. The scattering properties of unstained pathological prostate cancer slides and fresh cancerous and normal colon tissue samples are then investigated. A clear trend with cancer in the reduced scattering coefficient and the anisotropy factor is shown. The potential of the approach for tissue diagnosis is discussed at the end.

Paper Details

Date Published: 2 February 2012
PDF: 7 pages
Proc. SPIE 8230, Biomedical Applications of Light Scattering VI, 82300I (2 February 2012); doi: 10.1117/12.910457
Show Author Affiliations
Bianca DeAngelo, Fairfield Univ. (United States)
Grant Arzumanov, Fairfield Univ. (United States)
Patrick Shanley, Fairfield Univ. (United States)
Zhang Xu, Wenzhou Medical College (China)
M. Xu, Fairfield Univ. (United States)


Published in SPIE Proceedings Vol. 8230:
Biomedical Applications of Light Scattering VI
Adam P. Wax; Vadim Backman, Editor(s)

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