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Proceedings Paper

Ultrasensitive system for the real-time detection of H2O2 based on strong coupling in a bioplasmonic system
Author(s): S. Dutta-Gupta; G. Suarez; Ch. Santschi; L. Juillerat-Jeanneret; O. J. F. Martin
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Paper Abstract

We theoretically investigate the dependence of the different parameters of an optical biosensor for the detection of Hydrogen peroxide (H2O2) based on absorption enhancement of Cytochrome c molecules near gold nanoparticles. H2O2 is a major reactive oxygen species which is involved in signaling pathways and oxidative stress in cells. We use the Green's function approach as well as confirm the corresponding simulation results using the surface integral formulation. Further we show that this technique can be applied for detection of other small molecules, like oxygen and carbon monoxide.

Paper Details

Date Published: 6 February 2012
PDF: 6 pages
Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340K (6 February 2012); doi: 10.1117/12.910292
Show Author Affiliations
S. Dutta-Gupta, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
G. Suarez, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Ch. Santschi, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
L. Juillerat-Jeanneret, Institute of Pathology, Univ. of Lausanne (Switzerland)
O. J. F. Martin, Ecole Polytechnique Fédérale de Lausanne (Switzerland)

Published in SPIE Proceedings Vol. 8234:
Plasmonics in Biology and Medicine IX
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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