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Proceedings Paper

Primary motor cortex activity reduction under the regulation of SMA by real-time fMRI
Author(s): Jia Guo; Xiaojie Zhao; Yi Li; Li Yao; Kewei Chen
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Paper Abstract

Real-time fMRI (rtfMRI) is a new technology which allows human subjects to observe and control their own BOLD signal change from one or more localized brain regions during scanning. Current rtfMRI-neurofeedback studies mainly focused on the target region itself without considering other related regions influenced by the real-time feedback. However, there always exits important directional influence between many of cooperative regions. On the other hand, rtfMRI based on motor imagery mainly aimed at somatomotor cortex or primary motor area, whereas supplement motor area (SMA) was a relatively more integrated and pivotal region. In this study, we investigated whether the activities of SMA can be controlled utilizing different motor imagery strategies, and whether there exists any possible impact on an unregulated but related region, primary motor cortex (M1). SMA was first localized using overt finger tapping task, the activities of SMA were feedback to subjects visually on line during each of two subsequent imagery motor movement sessions. All thirteen healthy participants were found to be able to successfully control their SMA activities by self-fit imagery strategies which involved no actual motor movements. The activation of right M1 was also found to be significantly reduced in both intensity and extent with the neurofeedback process targeted at SMA, suggestive that not only the part of motor cortex activities were influenced under the regulation of a key region SMA, but also the increased difference between SMA and M1 might reflect the potential learning effect.

Paper Details

Date Published: 12 April 2012
PDF: 7 pages
Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 831704 (12 April 2012); doi: 10.1117/12.910080
Show Author Affiliations
Jia Guo, Beijing Normal Univ. (China)
Xiaojie Zhao, Beijing Normal Univ. (China)
Yi Li, Beijing Normal Univ. (China)
Li Yao, Beijing Normal Univ. (China)
Kewei Chen, Banner Good Samaritan Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8317:
Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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