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Proceedings Paper

Quantitative measurement of cerebral blood flow during hypothermia with a time-resolved near-infrared technique
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Paper Abstract

Hypothermia, in which the brain is cooled to 32-33 °C, has been shown to be neuroprotective for brain injury caused by hypoxia-ischemia, head trauma, or neonatal asphyxia. Neuroprotective effect of Hypothermia is partly due to suppression of brain metabolism and cerebral blood flow (CBF). The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neuro intensive care before brain injury occurs. The purpose of the present study is to investigate the ability of a time-resolved near-infrared (TR-NIR) bolus-tracking method using indocyanine green as an intravascular flow tracer to measure CBF during cooling in a newborn animal model. For validation, CBF was independently measured by computed tomography (CT) perfusion. The results show a good agreement between CBF obtained with the two methods (R2 ≈ 0.84, Δ ≈ 5.84 ml. min -1.100 g -1, 32-38.5 °C), demonstrating the ability of the TR-NIR technique to non-invasively measure absolute CBF in-vivo during dynamic hypothermia. The TR-NIR technique reveals that CBF decreases from 54.3 ± 5.4 ml. min -1.100 g -1, at normothermia (Tbrain of 38.5 °C), to 33.8 ± 0.9 ml. min -1.100 g -1 at Tbrain of 32 °C during the hypothermia treatment.

Paper Details

Date Published: 9 February 2012
PDF: 8 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074R (9 February 2012); doi: 10.1117/12.909734
Show Author Affiliations
Mohammad Fazel Bakhsheshi, Lawson Health Research Institute (Canada)
Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Mamadou Diop, Lawson Health Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Keith St Lawrence, Lawson Health Research Institute (Canada)
Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Ting-Yim Lee, Lawson Health Research Institute (Canada)
Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; E. Duco Jansen; Andreas Mandelis; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Melissa J. Suter; Stephen Lam; Matthew Brenner; Hyun Wook Kang; Bodo E. Knudsen; Henry Hirschberg; Steen Madsen; Brian Jet-Fei Wong; Justus F. Ilgner; Krzysztof Izdebski, Editor(s)

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