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Proceedings Paper

Multispectral optical tweezers for molecular diagnostics of single biological cells
Author(s): Corey Butler; Shima Fardad; Alex Sincore; Marie Vangheluwe; Matthieu Baudelet; Martin Richardson
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Paper Abstract

Optical trapping of single biological cells has become an established technique for controlling and studying fundamental behavior of single cells with their environment without having "many-body" interference. The development of such an instrument for optical diagnostics (including Raman and fluorescence for molecular diagnostics) via laser spectroscopy with either the "trapping" beam or secondary beams is still in progress. This paper shows the development of modular multi-spectral imaging optical tweezers combining Raman and Fluorescence diagnostics of biological cells.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X, 82250C (9 February 2012); doi: 10.1117/12.909666
Show Author Affiliations
Corey Butler, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Shima Fardad, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Alex Sincore, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Marie Vangheluwe, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Matthieu Baudelet, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)
Martin Richardson, CREOL, The College of Optics and Photonics, Univ. of Central Florida (United States)


Published in SPIE Proceedings Vol. 8225:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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