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Proceedings Paper

Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach
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Paper Abstract

Determining the structure of lung tissue is difficult in ex-vivo samples. Optical coherence tomography (OCT) can image alveoli but ignores optical effects that distort the images. For example, light refracts and changes speed at the alveolar air-tissue surface. We employ ray-tracing to model OCT imaging with directional and speed changes included, using spherical shapes in 2D. Results show apparent thickening of inter-aveolar walls and distortion of shape and depth. Our approach suggests a correction algorithm by combining the model with image analysis. Distortion correction will allow inference of tissue mechanical properties and deeper imaging.

Paper Details

Date Published: 10 February 2012
PDF: 5 pages
Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 82271R (10 February 2012); doi: 10.1117/12.909649
Show Author Affiliations
Fatemeh N. Golabchi, Northeastern Univ. (United States)
Ali Golabchi, Northeastern Univ. (United States)
Dana H. Brooks, Northeastern Univ. (United States)
Andrew Gouldstone, Northeastern Univ. (United States)
Charles A. DiMarzio, Northeastern Univ. (United States)

Published in SPIE Proceedings Vol. 8227:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson; Thomas G. Brown, Editor(s)

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