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Proceedings Paper

A study on the spectral dependence of second harmonic generation from collagen tissues
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Paper Abstract

The spectral dependence of SHG intensity in biological tissues is an optical property that is not fully understood so far. In this paper, we will investigate this problem in detail through experiments. Through examining different biology tissues, it is found that SHG intensity drops down from shorter to longer wavelength from 375 nm to 460 nm. By comparing these curves with 1/λn dependence, the n is found to vary from 4.5 to 8.5. These patterns can not be fully explained by scattering properties of collagen. Other factors such as direct generation of SHG may have contribution to these wavelength dependence patterns, which needs further investigation.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8226, Multiphoton Microscopy in the Biomedical Sciences XII, 82263R (9 February 2012); doi: 10.1117/12.909646
Show Author Affiliations
Mengzhe Shen, The Univ. of British Columbia (Canada)
Hequn Wang, The BC Cancer Research Ctr. and Photomedicine Institute (Canada)
Anthony Lee, The BC Cancer Research Ctr. and Photomedicine Institute (Canada)
Jianhua Zhao, The BC Cancer Research Ctr. and Photomedicine Institute (Canada)
Haishan Zeng, The BC Cancer Research Ctr. and Photomedicine Institute (Canada)
Shuo Tang, The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 8226:
Multiphoton Microscopy in the Biomedical Sciences XII
Karsten König, Editor(s)

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