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Proceedings Paper

Neuron absorption study and mid-IR optical excitations
Author(s): Dingkai Guo; Xing Chen; Shilpa Vadala; Jennie Leach; Yordan Kostov; William W. Bewley; Chul-Soo Kim; Mijin Kim; Chadwick L. Canedy; Charles D. Merritt; Igor Vurgaftman; Jerry R. Meyer; Fow-Sen Choa
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Paper Abstract

Neuronal optical excitation can provide non-contacting tools to explore brain circuitry and a durable stimulation interface for cardiac pacing and visual as well as auditory sensory neuronal stimulation. To obtain accurate absorption spectra, we scan the transmission of neurons in cell culture medium, and normalize it by subtracting out the absorption spectrum of the medium alone. The resulting spectra show that the main neuronal absorption peaks are in the 3000- 6000nm band, although there is a smaller peak near 1450nm. By coupling the output of a 3μm interband cascade laser (ICL) into a mid-IR fluorozirconate fiber, we can effectively deliver more than 1J/cm2 photon intensity to the excitation site for neuronal stimulation.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82075O (9 February 2012); doi: 10.1117/12.909561
Show Author Affiliations
Dingkai Guo, Univ. of Maryland, Baltimore County (United States)
Xing Chen, Univ. of Maryland, Baltimore County (United States)
Shilpa Vadala, Univ. of Maryland, Baltimore County (United States)
Jennie Leach, Univ. of Maryland, Baltimore County (United States)
Yordan Kostov, Univ. of Maryland, Baltimore County (United States)
William W. Bewley, U.S. Naval Research Lab. (United States)
Chul-Soo Kim, U.S. Naval Research Lab. (United States)
Mijin Kim, U.S. Naval Research Lab. (United States)
Chadwick L. Canedy, U.S. Naval Research Lab. (United States)
Charles D. Merritt, U.S. Naval Research Lab. (United States)
Igor Vurgaftman, U.S. Naval Research Lab. (United States)
Jerry R. Meyer, U.S. Naval Research Lab. (United States)
Fow-Sen Choa, Univ. of Maryland, Baltimore County (United States)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; E. Duco Jansen; Andreas Mandelis; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Melissa J. Suter; Stephen Lam; Matthew Brenner; Hyun Wook Kang; Bodo E. Knudsen; Henry Hirschberg; Steen Madsen; Brian Jet-Fei Wong; Justus F. Ilgner; Krzysztof Izdebski, Editor(s)

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