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Proceedings Paper

Profiling wound healing with wound effluent: Raman spectroscopic indicators of infection
Author(s): Nicole J. Crane; Eric A. Elster
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Paper Abstract

The care of modern traumatic war wounds remains a significant challenge for clinicians. Many of the extremity wounds inflicted during Operation Enduring Freedom and Operation Iraqi Freedom are colonized or infected with multi-drug resistant organisms, particularly Acinetobacter baumannii. Biofilm formation and resistance to current treatments can significantly confound the wound healing process. Accurate strain identification and targeted drug administration for the treatment of wound bioburden has become a priority for combat casualty care. In this study, we use vibrational spectroscopy to examine wound exudates for bacterial load. Inherent chemical differences in different bacterial species and strains make possible the high specificity of vibrational spectroscopy.

Paper Details

Date Published: 31 January 2012
PDF: 8 pages
Proc. SPIE 8220, Optical Biopsy X, 82200S (31 January 2012); doi: 10.1117/12.909405
Show Author Affiliations
Nicole J. Crane, Naval Medical Research Ctr. (United States)
Eric A. Elster, Naval Medical Research Ctr. (United States)
Uniformed Services Univ. of Health Sciences (United States)
Walter Reed National Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8220:
Optical Biopsy X
Robert R. Alfano; Stavros G. Demos, Editor(s)

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