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Proceedings Paper

Coaxial electrospray for multimodal imaging and image-guided therapy
Author(s): Ting Si; Leilei Zhang; Guangbin Li; Cynthia J. Roberts; Laibin Jia; Xiezhen Yin; Ronald Xu
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Paper Abstract

Recent development in multimodal imaging and image-guided therapy requires multifunctional microparticles that encapsulate several imaging and therapeutic agents in the same carrier for simultaneous detection and treatment of the diseases. However, commonly used microfabrication processes for these microparticles have multiple limitations such as the low encapsulation efficiency and the loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both the experimental and the theoretical studies on coaxial electrospray of poly(lactide-co-glycolide) PLGA microparticles. On the experimental side, a coaxial electrospray setup has been developed and tested. The setup consists of a customized coaxial needle assembly, two ring electrodes, two high-voltage power supplies, two syringe infusion pumps, a particle collection reservoir, and a process monitoring system. On the theoretical side, a classical normal mode method has been used for instability analysis of the coaxial electrified jet based on the experimental parameters. The effects of different dimensionless process parameters on the formation of different unstable modes have also been studied. The reported research represents the first step toward the quantitative control and optimization of the coaxial electrospray process for the fabrication of multifunctional microparticles in multimodal imaging and image-guided therapy.

Paper Details

Date Published: 29 February 2012
PDF: 10 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160M (29 February 2012); doi: 10.1117/12.909383
Show Author Affiliations
Ting Si, Univ. of Science and Technology of China (China)
Leilei Zhang, The Ohio State Univ. (United States)
Guangbin Li, Univ. of Science and Technology of China (China)
Cynthia J. Roberts, The Ohio State Univ. (United States)
Laibin Jia, Univ. of Science and Technology of China (China)
Xiezhen Yin, Univ. of Science and Technology of China (China)
Ronald Xu, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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