Share Email Print
cover

Proceedings Paper

Effect of light scattering on optical-resolution photoacoustic microscopy
Author(s): Yan Liu; Chi Zhang; Song Hu; Yuta Suzuki; Zhun Xu; Silvina Ferradal; Lihong V. Wang
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

The penetration depth of ballistic optical imaging technologies is limited by light scattering. To study the effect of scattering on optical-resolution photoacoustic microscopy (OR-PAM), we divided the signals in OR-PAM into two classes: one is from the target volume defined by the optical resolution cell (Class I); the other is from the rest of the acoustic resolution cell (Class II). We developed a way to simulate the point spread function (PSF) of our OR-PAM system considering both optical illumination and acoustic detection, then used the PSF to calculate the contributions of each class of signal to the total signal at different focal depths. Our simulation results showed that: 1) The Class II signal decays much more slowly than the Class I signal; 2) The full width at half maximum (FWHM) of the PSF for the focal depth of 0.9 transport mean free path (TMFP) is not broadened much (~10%) compared with that for a clear medium; 3) Image contrast is degraded with increasing depth when there is a uniform absorption background.

Paper Details

Date Published: 23 February 2012
PDF: 6 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82233S (23 February 2012); doi: 10.1117/12.909373
Show Author Affiliations
Yan Liu, Washington Univ. in St. Louis (United States)
Chi Zhang, Washington Univ. in St. Louis (United States)
Song Hu, Washington Univ. in St. Louis (United States)
Yuta Suzuki, Washington Univ. in St. Louis (United States)
Zhun Xu, Washington Univ. in St. Louis (United States)
Silvina Ferradal, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top