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Proceedings Paper

Prenatal imaging of distal limb abnormalities using OCT in mice
Author(s): Irina V. Larina; Saba H. Syed; Mary E. Dickinson; Paul Overbeek; Kirill V. Larin
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Paper Abstract

Congenital abnormalities of the limbs are common birth defects. These include missing or extra fingers or toes, abnormal limb length, and abnormalities in patterning of bones, cartilage or muscles. Optical Coherence Tomography (OCT) is a 3-D imaging modality, which can produce high-resolution (~8 μm) images of developing embryos with an imaging depth of a few millimeters. Here we demonstrate the capability of OCT to perform 3D imaging of limb development in normal embryos and a mouse model with congenital abnormalities. Our results suggest that OCT is a promising tool to analyze embryonic limb development in mammalian models of congenital defects.

Paper Details

Date Published: 30 January 2012
PDF: 4 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82130B (30 January 2012); doi: 10.1117/12.909266
Show Author Affiliations
Irina V. Larina, Baylor College of Medicine (United States)
Saba H. Syed, Baylor College of Medicine (United States)
Mary E. Dickinson, Baylor College of Medicine (United States)
Paul Overbeek, Baylor College of Medicine (United States)
Kirill V. Larin, Baylor College of Medicine (United States)
Univ. of Houston (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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