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Proceedings Paper

Diffuse reflectance spectral imaging for breast tumor margin assessment
Author(s): Justin Y. Lo; Sulochana Dhar; Bing Yu; Martin A. Brooke; Thomas F. Kuech; Nan M. Jokerst; Nimmi Ramanujam
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Paper Abstract

Diffuse reflectance spectroscopy has been previously explored as a promising method for providing real-time visual maps of tissue composition to help surgeons determine breast lumpectomy margins and to ensure the complete removal of a tumor during surgery. We present the simple design, validation, and implementation of a compact and cost-effective spectral imaging system for the application of tumor margin assessment. Our new system consists of a broadband source with bandpass filters for illumination and a fabricated custom 16-pixel photodiode imaging array for the detection of diffuse reflectance. The system prototype was characterized in tissue-mimicking phantoms and has an SNR of greater than 40 dB in phantoms, animals, and human tissue. We show proof-of-concept for performing fast, wide-field spectral imaging with a simple, inexpensive design. The strategy also allows for the scaling to higher pixel number and density in future iterations of the system.

Paper Details

Date Published: 22 February 2012
PDF: 7 pages
Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821407 (22 February 2012); doi: 10.1117/12.909259
Show Author Affiliations
Justin Y. Lo, Duke Univ. (United States)
Sulochana Dhar, Duke Univ. (United States)
Bing Yu, Duke Univ. (United States)
Martin A. Brooke, Duke Univ. (United States)
Thomas F. Kuech, Univ. of Wisconsin-Madison (United States)
Nan M. Jokerst, Duke Univ. (United States)
Nimmi Ramanujam, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 8214:
Advanced Biomedical and Clinical Diagnostic Systems X
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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