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Proceedings Paper

Estimation of surface wave propagation in mouse cornea
Author(s): Ravi Kiran Manapuram; Floredes M. Menodiado; Phiet Truong; Salavat Aglyamov; Stanislav Emelianov; Michael Twa; Kirill V. Larin
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Paper Abstract

In this paper, we report the use of phase stabilized swept source optical coherence tomography (PhSSSOCT) for the measurement of surface mechanical wave propagation in ocular tissue in-situ. Mechanical wave propagation was measured in the mouse cornea for both young and older mice to assess tissue properties as a function of age. The measurements were performed by inducing low amplitude (< 100 μm) waves and measuring the wave attenuation at spatially distributed points using a phase-sensitive analysis of OCT signals. Obtained results indicate that the attenuation of the wave amplitude was 0.27 μm/mm in the one month-old mouse cornea and 0.37 μm/mm for 9 month old mice (and presumably of different stiffness for 1 month and 9 months old). Results also suggest that PhS-SSOCT is capable of measuring the changes in the wave amplitude as small as 0.03 μm (limited by the phase stability of the system) that allowed the measurements with a very low amplitude excitation wave, thus making the method minimally invasive. Therefore, this method could potentially be used to assess tissue biomechanical properties and to reconstruct stiffness maps of the cornea.

Paper Details

Date Published: 9 March 2012
PDF: 9 pages
Proc. SPIE 8209, Ophthalmic Technologies XXII, 82090S (9 March 2012); doi: 10.1117/12.909229
Show Author Affiliations
Ravi Kiran Manapuram, Univ. of Houston (United States)
Floredes M. Menodiado, Univ. of Houston (United States)
Phiet Truong, Univ. of Houston (United States)
Salavat Aglyamov, Univ. of Texas at Austin (United States)
Stanislav Emelianov, Univ. of Texas at Austin (United States)
Michael Twa, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 8209:
Ophthalmic Technologies XXII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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