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Proceedings Paper

Study of aggressiveness prediction of mammary adenocarcinoma by Raman spectroscopy
Author(s): Renata Andrade Bitar; Herculano da Silva Martinho; Leandra Náira Zambelli Ramalho; Arnaldo Rodrigues dos Santos Junior; Fernando Silva Ramalho; Leandro Raniero; Airton A. Martin
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Paper Abstract

Although there are many articles focused on in vivo or ex vivo Raman analysis for cancer diagnosis, to the best of our knowledge its potential to predict the aggressiveness of tumor has not been fully explored yet. In this work Raman spectra in the finger print region of ex vivo breast tissues of both healthy mice (normal) and mice with induced mammary gland tumors (abnormal) were measured and associated to matrix metalloproteinase-19 (MMP-19) immunohistochemical exam. It was possible to verify that normal breast, benign lesions, and adenocarcinomas spectra, including the subtypes (cribriform, papillary and solid) could have their aggressiveness diagnosed by vibrational Raman bands. By using MMP- 19 exam it was possible to classify the samples by malignant graduation in accordance to the classification results of Principal Component Analysis (PCA). The spectra NM /MH were classified correctly in 100% of cases; CA/CPA group had 60 % of spectra correctly classified and for PA/AS 54% of the spectra were correctly classified.

Paper Details

Date Published: 31 January 2012
PDF: 7 pages
Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 821914 (31 January 2012); doi: 10.1117/12.909159
Show Author Affiliations
Renata Andrade Bitar, Univ. Federal do ABC (Brazil)
Univ. do Vale do Paraíba (Brazil)
Herculano da Silva Martinho, Univ. Federal do ABC (Brazil)
Leandra Náira Zambelli Ramalho, Univ. de São Paulo (Brazil)
Arnaldo Rodrigues dos Santos Junior, Univ. Federal do ABC (Brazil)
Fernando Silva Ramalho, Univ. de São Paulo (Brazil)
Leandro Raniero, Univ. do Vale do Paraíba (Brazil)
Airton A. Martin, Univ. do Vale do Paraíba (Brazil)

Published in SPIE Proceedings Vol. 8219:
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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