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Proceedings Paper

In vivo combined photoacoustic and Doppler ultrasound imaging
Author(s): Yan Jiang; Tyler Harrison; Alexander Forbrich; Roger J. Zemp
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Paper Abstract

The long-term goal of our research is to develop photoacoustic and Doppler ultrasound imaging methods for noninvasive estimation of the oxygen consumption rate (MRO2) in vivo. Previously, we have demonstrated a combined photoacoustic and high-frequency Doppler ultrasound system and shown the feasibility of flow velocity and oxygen saturation (sO2) estimation using double-ink flow phantoms. In this work, the results of in vitro sheep blood experiments are presented. Blood oxygen flux has been estimated at different sO2 levels and mean flow speeds, and the uncertainty of the measurement has been quantified. In vivo experiments have been performed on Swiss Webster mice to provide coregistered photoacoustic and Doppler flow images with imaging depths of ~2mm. Doppler bandwidth broadening technique has been used to obtain transverse flow velocity. The diameter of the blood vessel is ~500μm and the mean flow speed is 15cm/s. We are working towards sO2 estimation in vivo and 3D oxygen consumption imaging of tumors at depths beyond OR-PAM.

Paper Details

Date Published: 23 February 2012
PDF: 9 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822315 (23 February 2012); doi: 10.1117/12.909157
Show Author Affiliations
Yan Jiang, Univ. of Alberta (Canada)
Tyler Harrison, Univ. of Alberta (Canada)
Alexander Forbrich, Univ. of Alberta (Canada)
Roger J. Zemp, Univ. of Alberta (Canada)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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