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Proceedings Paper

Optoacoustic temperature monitoring during HIFU impact on biological tissues: ex vivo study and numerical simulations of 2D temperature reconstruction
Author(s): Sergey Nikitin; Tatiana Khokhlova; Ivan Pelivanov
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Paper Abstract

Dependencies of the optoacoustic (OA) transformation efficiency on tissue temperature were obtained for the application in OA temperature monitoring during thermal therapies. Accurate measurement of the OA signal amplitude versus temperature was performed in different ex-vivo tissues in the temperature range 25°C - 80°C. The investigated tissues were selected to represent different structural components: chicken breast (skeletal muscle), porcine lard (fatty tissue) and porcine liver (richly perfused tissue). Backward mode of the OA signal detection and a narrow probe laser beam were used in the experiments to avoid the influence of changes in light scattering with tissue coagulation on the OA signal amplitude. Measurements were performed in heating and cooling regimes. Characteristic behavior of the OA signal amplitude temperature dependences in different temperature ranges were described in terms of changes in different structural components of the tissue samples. Finally, numerical simulation of the OA temperature monitoring with a linear transducers array was performed to demonstrate the possibility of real-time temperature mapping.

Paper Details

Date Published: 28 February 2012
PDF: 14 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822313 (28 February 2012); doi: 10.1117/12.909079
Show Author Affiliations
Sergey Nikitin, M.V. Lomonosov Moscow State Univ. (Russian Federation)
Tatiana Khokhlova, M.V. Lomonosov Moscow State Univ. (Russian Federation)
Ivan Pelivanov, M.V. Lomonosov Moscow State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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