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Proceedings Paper

Intraoperative laser speckle contrast imaging for monitoring cerebral blood flow: results from a 10-patient pilot study
Author(s): Lisa M. Richards; Erica L. Weber; Ashwin B. Parthasarathy; Kaelyn L. Kappeler; Douglas J. Fox; Andrew K. Dunn
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Paper Abstract

Monitoring cerebral blood flow (CBF) during neurosurgery can provide important physiological information for a variety of surgical procedures. Although multiple intraoperative vascular monitoring technologies are currently available, a quantitative method that allows for continuous monitoring is still needed. Laser speckle contrast imaging (LSCI) is an optical imaging method with high spatial and temporal resolution that has been widely used to image CBF in animal models in vivo. In this pilot clinical study, we adapted a Zeiss OPMI Pentero neurosurgical microscope to obtain LSCI images by attaching a camera and a laser diode. This LSCI adapted instrument has been used to acquire full field flow images from 10 patients during tumor resection procedures. The patient's ECG was recorded during acquisition and image registration was performed in post-processing to account for pulsatile motion artifacts. Digital photographs confirmed alignment of vasculature and flow images in four cases, and a relative change in blood flow was observed in two patients after bipolar cautery. The LSCI adapted instrument has the capability to produce real-time, full field CBF image maps with excellent spatial resolution and minimal intervention to the surgical procedure. Results from this study demonstrate the feasibility of using LSCI to monitor blood flow during neurosurgery.

Paper Details

Date Published: 9 February 2012
PDF: 12 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074L (9 February 2012); doi: 10.1117/12.909078
Show Author Affiliations
Lisa M. Richards, The Univ. of Texas at Austin (United States)
Erica L. Weber, The Univ. of Texas at Austin (United States)
Ashwin B. Parthasarathy, Boston Univ. (United States)
Kaelyn L. Kappeler, St David's Hospital (United States)
Douglas J. Fox, St. David's Hospital (United States)
Andrew K. Dunn, The Univ. of Texas at Austin (United States)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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