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Proceedings Paper

Trapping and dynamic manipulation with magnetomotive photoacoustic imaging of targeted microspheres mimicking metastatic cancer cells trafficking in the vasculature
Author(s): Chenwei Wei; Jinjun Xia; Ivan Pelivanov; Xiaoge Hu; Xiaohu Gao; Matthew O'Donnell
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Paper Abstract

Trapping and manipulation of micro-scale objects mimicking metastatic cancer cells in a flow field have been demonstrated with magnetomotive photoacoustic (mmPA) imaging. Coupled contrast agents combining gold nanorods (15 nm × 50 nm; absorption peak around 730 nm) with 15 nm diameter magnetic nanospheres were targeted to 10 μm polystyrene beads recirculating in a 1.6 mm diameter tube mimicking a human peripheral vessel. Targeted objects were then trapped by an external magnetic field produced by a dual magnet system consisting of two disc magnets separated by 6 cm to form a polarizing field (0.04 Tesla in the tube region) to magnetize the magnetic contrast agents, and a custom designed cone magnet array with a high magnetic field gradient (about 0.044 Tesla/mm in the tube region) producing a strong trapping force to magnetized contrast agents. Results show that polystyrene beads linked to nanocomposites can be trapped at flow rates up to 12 ml/min. It is shown that unwanted background in a photoacoustic image can be significantly suppressed by changing the position of the cone magnet array with respect to the tube, thus creating coherent movement of the trapped objects. This study makes mmPA imaging very promising for differential visualization of metastatic cells trafficking in the vasculature.

Paper Details

Date Published: 23 February 2012
PDF: 7 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82231R (23 February 2012); doi: 10.1117/12.909053
Show Author Affiliations
Chenwei Wei, Univ. of Washington (United States)
Jinjun Xia, Univ. of Washington (United States)
Ivan Pelivanov, Univ. of Washington (United States)
M.V. Lomonosov Moscow State Univ. (Russian Federation)
Xiaoge Hu, Univ. of Washington (United States)
Xiaohu Gao, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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