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Proceedings Paper

Simultaneous in vivo imaging of melanin and lipofuscin in the retina with multimodal photoacoustic ophthalmoscopy
Author(s): Xiangyang Zhang; Hao F. Zhang; Lixiang Zhou; Shuliang Jiao
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Paper Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective vs. exacerbate) in the RPE in the aging process. We successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

Paper Details

Date Published: 23 February 2012
PDF: 6 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822305 (23 February 2012); doi: 10.1117/12.908820
Show Author Affiliations
Xiangyang Zhang, The Univ. of Southern California (United States)
Hao F. Zhang, Northwestern Univ. (United States)
Lixiang Zhou, The Univ. of Southern California (United States)
Shuliang Jiao, The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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