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Proceedings Paper

Breast cancer imaging and tomography using a hand-held optical imager
Author(s): Sarah J. Erickson; Manuela Roman; Jean Gonzalez; Richard Kiszonas; Cristina Lopez-Penalver; Anuradha Godavarty
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Paper Abstract

Hand-held optical imaging devices are currently developed by several research groups as a noninvasive and non-ionizing method towards clinical imaging of breast cancer. The devices developed to date are typically utilized towards spectroscopic imaging via reflectance-based measurements. Additionally, a couple of devices have been used to perform 3D tomography with the addition of a second modality (e.g. ultrasound). A hand-held optical device that is unique in its ability to perform rapid 2D imaging and 3D tomography (without the use of a second modality) has been developed in our Optical Imaging laboratory. Herein, diffuse optical imaging studies are performed in breast cancer subjects. For these studies, the subject lay in a recliner chair and both breast tissues were imaged with the hand-held optical device which uses 785 nm laser source and an intensified CCD camera-based detector. Preliminary results demonstrate the ability to image invasive ductal carcinoma and lymphatic spread, as compared to the patient's medical records (e.g. xray, ultrasound, MRI). Multiple imaging studies with a subject undergoing chemotherapy demonstrated the potential to monitor response to treatment. Currently, studies are carried out to tomographically determine the 3D location of the tumor(s) in breast cancer subjects using the hand-held optical device.

Paper Details

Date Published: 28 February 2012
PDF: 9 pages
Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82140Q (28 February 2012); doi: 10.1117/12.908528
Show Author Affiliations
Sarah J. Erickson, Florida International Univ. (United States)
Manuela Roman, Florida International Univ. (United States)
Jean Gonzalez, Florida International Univ. (United States)
Richard Kiszonas, Sylvester Comprehensive Cancer Ctr. (United States)
Cristina Lopez-Penalver, Advanced Medical Specialities (United States)
Anuradha Godavarty, Florida International Univ. (United States)

Published in SPIE Proceedings Vol. 8214:
Advanced Biomedical and Clinical Diagnostic Systems X
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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