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Proceedings Paper

Transcutaneous monitoring of steroid-induced osteoporosis with Raman spectroscopy
Author(s): Jason R. Maher; Jason Inzana; Masahiko Takahata; Hani A. Awad; Andrew J. Berger
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Paper Abstract

Although glucocorticoids are among the most frequently prescribed anti-inflammatory agents used in the treatment of rheumatoid arthritis, extended exposure to this steroid hormone is the leading cause of iatrogenic osteoporosis. Recently, Raman spectroscopy has been utilized to exploit biochemical differences between osteoporotic and normal bones in order to predict fracture risk. In this presentation, we report the results of ongoing research in our laboratory towards the clinical translation of this technique. We will discuss strategies for the transcutaneous acquisition of spectra from the tibiae of mice that are of sufficient quality to generate accurate predictions of fracture risk.

Paper Details

Date Published: 31 January 2012
PDF: 7 pages
Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190P (31 January 2012); doi: 10.1117/12.908361
Show Author Affiliations
Jason R. Maher, Univ. of Rochester (United States)
Jason Inzana, Univ. of Rochester (United States)
Masahiko Takahata, Univ. of Rochester (United States)
Hani A. Awad, Univ. of Rochester (United States)
Andrew J. Berger, Univ. of Rochester (United States)

Published in SPIE Proceedings Vol. 8219:
Biomedical Vibrational Spectroscopy V: Advances in Research and Industry
Anita Mahadevan-Jansen; Wolfgang Petrich, Editor(s)

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