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Proceedings Paper

High resolution imaging of mouse anatomy and molecular probes in mice by means of multispectral optoacoustic tomography (MSOT)
Author(s): Andreas Buehler; Stefan Morscher; Daniel Razansky; Vasilis Ntziachristos
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Paper Abstract

The ability to detect molecular probes in deep tissue, based on optical signatures, has been limited by tissue scattering, which reduces the spatial resolution and complicates quantification. To address this challenge, multispectral optoacoustic tomography (MSOT) has been recently introduced, a hybrid technology that capitalizes on the optoacoustic effect to combine rich optical contrast with the high spatial resolution and real-time operation of ultrasound. Using multiwavelength illumination MSOT can visualize molecular probes based on their distinct optical absorption spectra through several millimeters to centimeters of tissue. Herein we present a whole body multi-spectral optoacoustic tomography system and report on spectral processing techniques for detection of molecular probes in living mice.

Paper Details

Date Published: 23 February 2012
PDF: 5 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230H (23 February 2012); doi: 10.1117/12.908230
Show Author Affiliations
Andreas Buehler, Technical Univ. Munich (Germany)
Helmholtz Zentrum Munich (Germany)
Stefan Morscher, Technical Univ. Munich (Germany)
Helmholtz Zentrum Munich (Germany)
Daniel Razansky, Technical Univ. Munich (Germany)
Helmholtz Zentrum Munich (Germany)
Vasilis Ntziachristos, Technical Univ. Munich (Germany)
Helmholtz Zentrum Munich (Germany)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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