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Proceedings Paper

Photoacoustic array imaging of calcifications: phantom study
Author(s): Yao-You Cheng; Tsai-Chu Hsiao; Wan-Ting Tien; Shih-Bin Luo; De-Yi Chiou; Meng-Lin Li
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Paper Abstract

Breast calcification is one of the most important indicators for early breast cancer detection. In this study, based on a medical ultrasound array imaging platform, we attempt to develop a real-time and high penetration photoacoustic (PA) array imaging system for visualization of breast calcifications. Phantom studies were used to verify the imaging capability and penetration depth of the developed PA array system for calcification imaging. Intralipid gelatin phantoms with different-sized hydroxyapatite (HA) particles - major chemical composition of the breast calcification associated with malignant breast cancers - embedded were imaged. Laser at 750 nm was used for photoacoustic excitation and a custom-made 5-MHz photoacoustic array transducer with linear light guides was applied for photoacoustic signal detection. Experimental results demonstrated that this system is capable of calcification imaging of 0.3-0.5 mm HA particles. For the 0.5-mm HA particles, the imaging contrast was about 34 dB and the achievable penetration was 20 mm where the axial, lateral, and elevational resolution of this PA array imaging system is 0.39 mm, 0.38 mm, and 1.25 mm, respectively. The highest frame rate was 10 frames/sec limited by the laser pulse rate. Overall, our results demonstrate that it is promising for PA imaging as a real-time diagnosis and biopsy guidance tool of breast micro-calcifications outside mass lesion. Future work will focus on optimization of the photoacoustic transducer to further improve the penetration depth and development of photoacoustic and ultrasound dual-modal imaging to enhance the calcification imaging capability.

Paper Details

Date Published: 23 February 2012
PDF: 6 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822335 (23 February 2012); doi: 10.1117/12.908206
Show Author Affiliations
Yao-You Cheng, National Tsing Hua Univ. (Taiwan)
Tsai-Chu Hsiao, National Tsing Hua Univ. (Taiwan)
Wan-Ting Tien, Industrial Technology Research Institute (Taiwan)
Shih-Bin Luo, Industrial Technology Research Institute (Taiwan)
De-Yi Chiou, Industrial Technology Research Institute (Taiwan)
Meng-Lin Li, National Tsing Hua Univ. (Taiwan)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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