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Proceedings Paper

Examination of a demyelinated fiber by action-potential-encoded second harmonic generation
Author(s): Xin-guang Chen; Zhi-hui Luo; Hong-qin Yang; Yi-mei Huang; Shu-sen Xie
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Paper Abstract

Axonal demyelination is a common phenomenon in the nervous system in human. Conventional measured approaches such as surface recording electrode and diffusion tensor imaging, are hard to fast and accurately determine the demyelinated status of a fiber. In this study, we first presented a mathematical model of nerve fiber demyelination, and it was combined with second harmonic generation(SHG) technique to study the characteristics of action-potential-encoded SHG and analyze the sensitivity of SHG signals responded to membrane potential. And then, we used this approach to fast examine the injured myelin sheaths resulted from demyelination. Each myelin sheath of a fiber was examined simultaneously by this approach. The results showed that fiber demyelination led to observable attenuation of action potential amplitude. The delay of action potential conduction would be markedly observed when the fiber demyelination was more than 80%. Furthermore, the normal and injured myelin sheaths of a myelinated fiber could be distinguished via the changes of SHG signals, which revealed the possibility of SHG technique in the examination of a demyelinated fiber. Our study shows that this approach may have potential application values in clinic.

Paper Details

Date Published: 29 February 2012
PDF: 8 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 821613 (29 February 2012); doi: 10.1117/12.908152
Show Author Affiliations
Xin-guang Chen, Fujian Normal Univ. (China)
Zhi-hui Luo, Fujian Normal Univ. (China)
Hong-qin Yang, Fujian Normal Univ. (China)
Yi-mei Huang, Fujian Normal Univ. (China)
Shu-sen Xie, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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