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Proceedings Paper

Bimodal BLT source reconstruction based on adjoint diffusion equations
Author(s): Yanbin Hou; Jimin Liang; Xiaochao Qu; Duofang Chen; Shouping Zhu; Jie Tian
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Paper Abstract

As one of molecular imaging, bioluminescence tomography (BLT) aims to recover internal source from surface measurement. Being an ill-posed inverse problem, BLT source reconstruction is usually converted to an optimization problem through regularization. In this contribution, we build a bimodal hybrid imaging system consisting of BLT and micro-CT, and then propose an improved source reconstruction method based on adjoint diffusion equations (ADEs). Compared with conventional methods based on constrained minimization problem (CMP), ADEs-based method replaces expensive iterative computation with solving a group of linear ADEs. Given surface flux density, internal source power density and photon fluence rate can be efficiently determined in one step. Both numerical and physical experiments are performed to evaluate the bimodal BLT/micro-CT imaging system and this novel reconstruction method. The relevant results demonstrate the feasibility and potential of this source reconstruction method.

Paper Details

Date Published: 29 February 2012
PDF: 8 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160R (29 February 2012); doi: 10.1117/12.908126
Show Author Affiliations
Yanbin Hou, Xidian Univ. (China)
Jimin Liang, Xidian Univ. (China)
Xiaochao Qu, Xidian Univ. (China)
Duofang Chen, Xidian Univ. (China)
Shouping Zhu, Xidian Univ. (China)
Jie Tian, Xidian Univ. (China)


Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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