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Proceedings Paper

Analyze fluorescent characteristic of cancer cell using hyperspectroscopic imaging system (HIS)
Author(s): Yao-Fang Hsieh; Chih-Hsien Chen; Ou-Yang Mang; Jeng-Ren Duann; Jin-Chern Chiou; Shun-De Wu; Yong-Jiun Lin; Ming-Hsui Tsai; Nai-Wen Chang
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Paper Abstract

Currently, the cancer was examined by diagnosing the pathological changes of tumor. If the examination of cancer can diagnose the tumor before the cell occur the pathological changes, the cure rate of cancer will increase. This research develops a human-machine interface for hyper-spectral microscope. The hyper-spectral microscope can scan the specific area of cell and records the data of spectrum and intensity. These data is helpful to diagnose tumor. This study finds the hyper-spectral imaging have two higher intensity points at 550nm and 700nm, and one lower point at 640nm between the two higher points. For analyzing the hyper-spectral imaging, the intensity at the 550nm peak divided by the intensity at 700nm peak. Finally, we determine the accuracy of detection by Gaussian distribution. The accuracy of detecting normal cells achieves 89%, and the accuracy of cancer cells achieves 81%.

Paper Details

Date Published: 3 February 2012
PDF: 6 pages
Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 822712 (3 February 2012); doi: 10.1117/12.907930
Show Author Affiliations
Yao-Fang Hsieh, National Central Univ. (Taiwan)
Chih-Hsien Chen, National Chiao Tung Univ. (Taiwan)
Ou-Yang Mang, National Chiao Tung Univ. (Taiwan)
Jeng-Ren Duann, China Medical Univ. (Taiwan)
Jin-Chern Chiou, National Chiao Tung Univ. (Taiwan)
Shun-De Wu, Taiwan Normal Univ. (Taiwan)
Yong-Jiun Lin, National Chiao-Tung Univ (Taiwan)
Ming-Hsui Tsai, China Medical Univ. (Taiwan)
Nai-Wen Chang, China Medical Univ. (Taiwan)


Published in SPIE Proceedings Vol. 8227:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson; Thomas G. Brown, Editor(s)

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