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Proceedings Paper

Absolute measurement of subnanometer scale vibration of cochlear partition of an excised guinea pig cochlea using spectral-domain phase-sensitive optical coherence tomography
Author(s): Hrebesh M. Subhash; Niloy Choudhury; Steven L. Jacques; Ruikang K. Wang; Fangyi Chen; Dingjun Zha; Alfred L. Nuttall
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Paper Abstract

Direct measurement of absolute vibration parameters from different locations within the mammalian organ of Corti is crucial for understanding the hearing mechanics such as how sound propagates through the cochlea and how sound stimulates the vibration of various structures of the cochlea, namely, basilar membrane (BM), recticular lamina, outer hair cells and tectorial membrane (TM). In this study we demonstrate the feasibility a modified phase-sensitive spectral domain optical coherence tomography system to provide subnanometer scale vibration information from multiple angles within the imaging beam. The system has the potential to provide depth resolved absolute vibration measurement of tissue microstructures from each of the delay-encoded vibration images with a noise floor of ~0.3nm at 200Hz.

Paper Details

Date Published: 18 February 2012
PDF: 7 pages
Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82131V (18 February 2012); doi: 10.1117/12.907900
Show Author Affiliations
Hrebesh M. Subhash, Oregon Health & Science Univ. (United States)
Niloy Choudhury, Michigan Technological Univ. (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)
Univ. of Washington (United States)
Fangyi Chen, Oregon Health & Science Univ. (United States)
Dingjun Zha, Oregon Health & Science Univ. (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)


Published in SPIE Proceedings Vol. 8213:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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