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Proceedings Paper

Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the biogenic-substances
Author(s): Daisuke Kojima; Takashi Takuma; Asuka Inui; Wei Qi; Ryosuke Tsutsumi; Takehiko Yuzuriha; Hiroyasu Kagiyama; Akira Nishiyama; Ichirou Ishimaru
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Paper Abstract

We are aiming at the realization of the non-invasive measurement of the biogenic-substance, such as the blood glucose concentration, by the proposed imaging-type 2-dimensional Fourier spectroscopy. We had successfully obtained the spectroscopic tomography of the mouse's ear with the near-infrared radiation. The proposed Fourier-spectroscopic imaging can limit the measuring depth into the focal plane. So, we can set the focal plane as the measurement plane near the skin surface that is not affected by the optical diffusion of the biological tissues. To analyze the absorption coefficient in the specific wavelength at the vessel area, we can expect to acquire the blood glucose concentration in high accuracy. In the proposed method, we install the variable phase-filter into the optical Fourier transform plane of the imaging optics to give the arbitrary phase-shift to the half flux of objective beams. Because of the imaging optics, only the rays from the focal plane can contribute the formation of the interferogram. Thus, we can obtain the 2-dimensional spectra only on the focal plane. We had successfully obtained the distribution of the spectroscopic-absorption near the skin surface. We are trying to convert the absorptance into the glucose concentration by the quantitative spectroscopic image-processing.

Paper Details

Date Published: 3 February 2012
PDF: 7 pages
Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82290M (3 February 2012); doi: 10.1117/12.907892
Show Author Affiliations
Daisuke Kojima, Kagawa Univ. (Japan)
Takashi Takuma, Kagawa Univ. (Japan)
Asuka Inui, Kagawa Univ. (Japan)
Wei Qi, Kagawa Univ. (Japan)
Ryosuke Tsutsumi, Kagawa Univ. (Japan)
Takehiko Yuzuriha, Kagawa Univ. (Japan)
Hiroyasu Kagiyama, Kagawa Univ. (Japan)
Akira Nishiyama, Kagawa Univ. (Japan)
Ichirou Ishimaru, Kagawa Univ. (Japan)


Published in SPIE Proceedings Vol. 8229:
Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV
Gerard L. Coté; Robert J. Nordstrom, Editor(s)

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