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Proceedings Paper

Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection
Author(s): Shanshan Liang; Arya Saidi; Joe Jing; Gangjun Liu; Jiechen Yin; Jagat Narula; Zhongping Chen
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Paper Abstract

Coronary heart disease (like myocardial infarction) is caused by atherosclerosis. It cause over 30% of all deaths in North America and are the most common cause of death in European men under 65 years of age and the second most common cause in women. To diagnose this atherosclerosis before it gets rupture is the most effect way to increase the chance of survival for patients who suffer from this disease. The crucial tusk is how to find out vulnerable plaques. In resent years optical coherence tomography (OCT) has become a very useful tool for intravascular imaging, since it has high axial and transverse resolution. OCT can tell the detail structure inside the plaque like the thickness of plaque cap which is an important factor to identify vulnerable plaques. But we still need to find out the biochemical characteristics that is unique for vulnerable plaques (like inflammation). Fluorescence molecular imaging is a standard way to exam the biochemical property of biological samples. So we integrate these two techniques together into one probe. Our probe is comprised of a double-clad fiber (DCF) and a grin lens, and rotates with a micro mirror in front. The single-mode inner core of the DCF transmits both OCT and fluorescence excitation light, and the multimode inner cladding is used to detect fluorescence signal. In vitro result shows that this is a possible way for more accurate diagnose of vulnerable plaques.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82073Y (9 February 2012); doi: 10.1117/12.907836
Show Author Affiliations
Shanshan Liang, Beckman Laser Institute and Medical Clinic (United States)
Dalian Univ. of Technology (China)
Arya Saidi, Beckman Laser Institute and Medical Clinic (United States)
Joe Jing, Univ. of California, Irvine Medical Ctr. (United States)
Beckman Laser Institute and Medical Clinic (United States)
Gangjun Liu, Beckman Laser Institute and Medical Clinic (United States)
Jiechen Yin, Univ. of California, Irvine Medical Ctr. (United States)
Beckman Laser Institute and Medical Clinic (United States)
Jagat Narula, Univ. of California, Irvine Medical Ctr. (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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