Share Email Print

Proceedings Paper

Synthesis and characterization of NIR light-responsive LbL nanocapsules
Author(s): Xue-mei Chi; Jie Cao; Shu-nan Wan; Chang-li Du; Wei R. Chen; Yue-qing Gu
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this paper, near-infrared (NIR) light responsive polyelectrolyte multilayer capsules (PE/Au NRs@Dox) were successfully synthesized by layer-by-layer techniques. Gold nanorods with aspect ratio of 3.9, and a longitudinal absorbance peak at 765nm were prepared using seed-mediated method which used the cationic surfactant cetyltrimethylammonium bromide (CTAB) as a soft template and structure-guiding agent. Sequential layers of polyanions (sodium polystyrene sulfonate (PSS)) and polycations (poly diallyldimethylammonium chloride (PDADMAC)) were followed by adsorption of three BSA/PSS bilayers. The doxorubicin (Dox) is loaded by the electrostatic interaction. The release of Dox from the swelling polyelectrolyte complex PE/Au NRs@Dox was induced by the heat generated from gold nanorods under laser irradiation. Moreover, the in vitro cytotoxicity of PE/Au NRs@Dox and the doxorubicin release from the composites were investigated.

Paper Details

Date Published: 14 February 2012
PDF: 9 pages
Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240J (14 February 2012); doi: 10.1117/12.907783
Show Author Affiliations
Xue-mei Chi, China Pharmaceutical Univ. (China)
Jie Cao, China Pharmaceutical Univ. (China)
Shu-nan Wan, China Pharmaceutical Univ. (China)
Chang-li Du, China Pharmaceutical Univ. (China)
Wei R. Chen, Univ. of Central Oklahoma (United States)
Yue-qing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 8224:
Biophotonics and Immune Responses VII
Wei R. Chen, Editor(s)

© SPIE. Terms of Use
Back to Top