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Proceedings Paper

Three-dimensional calibration targets for optical coherence tomography
Author(s): Michelle Gabriele Sandrian; Pete Tomlins; Peter Woolliams; Janarthanan Rasakanthan; Graham CB Lee; Anna Yang; Boris Považay; Aneesh Alex; Kate Sugden; Wolfgang Drexler
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Paper Abstract

The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane resin and allowed to harden overnight. These samples were then etched using a precision micromachining femtosecond laser with a center wavelength of 1026 nm, 100kHz repetition rate and 450 fs pulse duration. A series of lines in depth were etched, varying the percentage of inscription energy and speed of the translation stage moving the target with respect to the laser. Samples were imaged with a dual wavelength spectral-domain OCT system (λ=800nm, ▵λ≈180nm, and λ=1325nm, ▵λ≈100nm) and point-spread function of nanoparticles within the target was measured.

Paper Details

Date Published: 2 February 2012
PDF: 7 pages
Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 822914 (2 February 2012); doi: 10.1117/12.907748
Show Author Affiliations
Michelle Gabriele Sandrian, Medizinische Univ. Wien (Austria)
Pete Tomlins, Queen Mary, Univ. of London (United Kingdom)
Peter Woolliams, National Physical Lab. (United Kingdom)
Janarthanan Rasakanthan, Aston Univ. (United Kingdom)
Graham CB Lee, Aston Univ. (United Kingdom)
Anna Yang, Medizinische Univ. Wien (Austria)
Boris Považay, Medizinische Univ. Wien (Austria)
Aneesh Alex, Medizinische Univ. Wien (Austria)
Kate Sugden, Aston Univ. (United Kingdom)
Wolfgang Drexler, Medizinische Univ. Wien (Austria)


Published in SPIE Proceedings Vol. 8229:
Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV
Gerard L. Coté; Robert J. Nordstrom, Editor(s)

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