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Proceedings Paper

Effect of capsid proteins to ICG mass ratio on fluorescent quantum yield of virus-resembling optical nano-materials
Author(s): Sharad Gupta; Gerardo Ico; Paul Matsumura; A. L. N. Rao; Valentine Vullev; Bahman Anvari
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Paper Abstract

We recently reported construction of a new type of optical nano-construct composed of genome-depleted plant infecting brome mosaic virus (BMV) doped with Indocyanine green (ICG), an FDA-approved chromophore. We refer to these constructs as optical viral ghosts (OVGs) since only the capsid protein (CP) subunits of BMV remain to encapsulate ICG. To utilize OVGs as effective nano-probes in fluorescence imaging applications, their fluorescence quantum yield needs to be maximized. In this study, we investigate the effect of altering the CP to ICG mass ratio on the fluorescent quantum yield of OVGs. Results of this study provide the basis for construction of OVGs with optimal amounts of CP and ICG to yield maximal fluorescence quantum yield.

Paper Details

Date Published: 24 February 2012
PDF: 8 pages
Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 82330I (24 February 2012); doi: 10.1117/12.907738
Show Author Affiliations
Sharad Gupta, Univ. of California, Riverside (United States)
Gerardo Ico, Univ. of California, Riverside (United States)
Paul Matsumura, Univ. of California, Riverside (United States)
A. L. N. Rao, Univ. of California, Riverside (United States)
Valentine Vullev, Univ. of California, Riverside (United States)
Bahman Anvari, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 8233:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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