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Proceedings Paper

Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging
Author(s): Sharad Gupta; Hailey Wilder; A. L. N. Rao; V. I. Vullev; Bahman Anvari
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Paper Abstract

We recently reported the construction of a new type of optically active nano-particles composed of genome-depleted plant infecting brome mosaic virus (BMV) doped with indocyanine green (ICG), an FDA-approved chromophore . We refer to these constructs as optical viral ghosts (OVGs) since only the capsid protein (CP) subunits of BMV remain to encapsulate ICG. Herein, we covalently conjugated the surface of OVGs with anti-epidermal growth factor receptors (anti-EGFR) to target cancerous human bronchial epithelial cells (C-HBECs) in-vitro. Our preliminary results demonstrate the utility of conjugated OVGs for targeted imaging of cancer cells.

Paper Details

Date Published: 25 February 2012
PDF: 7 pages
Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 82330S (25 February 2012); doi: 10.1117/12.907730
Show Author Affiliations
Sharad Gupta, Univ. of California, Riverside (United States)
Hailey Wilder, Univ. of California, Riverside (United States)
A. L. N. Rao, Univ. of California, Riverside (United States)
V. I. Vullev, Univ. of California, Riverside (United States)
Bahman Anvari, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 8233:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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