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Proceedings Paper

In-vivo imaging of inner retinal cellular morphology with adaptive optics - optical coherence tomography: challenges and possible solutions
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Paper Abstract

Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the outer layers of the human retina. Despite the significant progress in imaging cone and rod photoreceptor mosaics, visualization of cellular structures in the inner retina has been achieved only with extrinsic contrast agents that have not been approved for use with humans. In this paper we describe the main limiting factors in visualizing inner retinal cells and the methods we implemented to reduce their effects on images acquired with AO-OCT. These include improving the system point spread function (AO performance), monitoring of motion artifacts (retinal motion tracking), and speckle pattern reduction (temporal and spatial averaging). Results of imaging inner retinal morphology and the improvement offered by the new UC Davis AOOCT system with spatio-temporal image averaging are presented.

Paper Details

Date Published: 9 March 2012
PDF: 6 pages
Proc. SPIE 8209, Ophthalmic Technologies XXII, 82091G (9 March 2012); doi: 10.1117/12.907678
Show Author Affiliations
Robert J. Zawadzki, UC Davis Medical Ctr. (United States)
Steven M. Jones, Lawrence Livermore National Lab. (United States)
Dae Yu Kim, UC Davis Medical Ctr. (United States)
Lisa Poyneer, Lawrence Livermore National Lab. (United States)
Arlie G. Capps, UC Davis Medical Ctr. (United States)
Univ. of California, Davis (United States)
Bernd Hamann, Univ. of California, Davis (United States)
Scot S. Olivier, Lawrence Livermore National Lab. (United States)
John S. Werner, UC Davis Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8209:
Ophthalmic Technologies XXII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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