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Proceedings Paper

Multi-exposure laser speckle perfusion imaging for retinal blood flow
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Paper Abstract

Measurements of flow in retinal vessels is presented and compared with in vitro measurements on whole blood in capillaries ranging from 75 to 200μm diameter. The viewing angle of the capillaries and their range of size allows size-dependent effects to be investigated when estimating flow within actual vessels. Retinal measurements show a pulse effect. When this is removed by synchronisation, multi-exposure measurements show different spectral signature from single speed scatterers. Multi-exposure measurements of the retina demonstrate a varying contribution of stationary scatter across the field. Unlike scattering in dermal tissue, photons in retinal vessels must return by multiple scatter from moving Red Blood Cells, whose motion is directed. Speckle estimates of flow in retinal vessels are therefore possible.

Paper Details

Date Published: 15 February 2012
PDF: 7 pages
Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 822205 (15 February 2012); doi: 10.1117/12.907619
Show Author Affiliations
Evan Hirst, Industrial Research Ltd. (New Zealand)
Mike Andrews, Industrial Research Ltd. (New Zealand)
Oliver Thompson, Industrial Research Ltd. (New Zealand)
Univ. of Auckland (New Zealand)

Published in SPIE Proceedings Vol. 8222:
Dynamics and Fluctuations in Biomedical Photonics IX
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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