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Proceedings Paper

A time domain noncontact fluorescence tomography system for breast cancer diagnosis
Author(s): Hui Guo; Wei Meng; Tingting Wang; Jiao Li; Huijuan Zhao; Feng Gao
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Paper Abstract

A time domain noncontact fluorescence tomography system and the corresponding reconstruction algorithm towards the early diagnosis of breast cancer are developed. The time domain system based on the time-correlated single photon counting technique is adopted to provide both the high sensitivity in detection and good capability in multi-parameter reconstruction. Comparing to the conventional contact measurement mode, the noncontact system with light scanning can provide more measurement data for improving the spatial resolution of the images. The performance and efficacy of the system is evaluated with measurements on solid phantoms. For the phantom with single fluorescent target, the fluorescence yield and lifetime were simultaneously reconstructed with good quality. For the phantom with two fluorescent targets, the targets with the center-to-center separation of 20mm and the edge separation of 15mm can be distinguished. Measurements also show that the reconstructed yields are linear to the concentration of the fluorescence dye. The results demonstrated the potential of the system in the in vivo diagnosis of the early breast cancer.

Paper Details

Date Published: 29 February 2012
PDF: 10 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160Z (29 February 2012); doi: 10.1117/12.907575
Show Author Affiliations
Hui Guo, Tianjin Univ. (China)
Wei Meng, Tianjin Univ. (China)
Tingting Wang, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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