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Proceedings Paper

Towards spatial frequency domain optical imaging of neurovascular coupling in a mouse model of Alzheimer's disease
Author(s): Alexander J. Lin; Soren D. Konecky; Tyler B. Rice; Kim N. Green; Bernard Choi; Anthony J. Durkin; Bruce J. Tromberg
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Paper Abstract

Early neurovascular coupling (NVC) changes in Alzheimer's disease can potentially provide imaging biomarkers to assist with diagnosis and treatment. Previous efforts to quantify NVC with intrinsic signal imaging have required assumptions of baseline optical pathlength to calculate changes in oxy- and deoxy-hemoglobin concentrations during evoked stimuli. In this work, we present an economical spatial frequency domain imaging (SFDI) platform utilizing a commercially available LED projector, camera, and off-the-shelf optical components suitable for imaging dynamic optical properties. The fast acquisition platform described in this work is validated on silicone phantoms and demonstrated in neuroimaging of a mouse model.

Paper Details

Date Published: 9 February 2012
PDF: 6 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074U (9 February 2012); doi: 10.1117/12.907557
Show Author Affiliations
Alexander J. Lin, Beckman Laser Institute and Medical Clinic (United States)
Soren D. Konecky, Beckman Laser Institute and Medical Clinic (United States)
Tyler B. Rice, Beckman Laser Institute and Medical Clinic (United States)
Kim N. Green, Univ. of California, Irvine Medical Ctr. (United States)
Bernard Choi, Beckman Laser Institute and Medical Clinic (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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