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Proceedings Paper

Comparsion of light dose on topical ALA-mediated photodynamic therapy for DMBA-induced hamster buccal pouch premalignant lesions
Author(s): Deng-Fu Yang; Meng-Ke Tseng; Chung-Ji Liu; Yih-Chih Hsu
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Paper Abstract

Oral cancer has becomes the most prominent male cancer disease due to the local betel nut chewing habit combing with smoking and alcohol-drinking lifestyle. In order to minimize the systemic phototoxic effect of 5-aminolevulinic acid (ALA), this study was designed to use a topical ALA-mediated PDT for treatment of DMBA-induced hamster buccal pouch cancerous lesions. DMBA was applied to one of the buccal pouches of hamsters thrice a week for 8 to 10 weeks. Precancerous lesions were induced and proven by histological examination. These DMBA-induced cancerous lesions were used for testing the efficacy of topical ALA -mediated PDT. We found that ALA reached its peak level in cancerous lesions about 2.5 hrs after topical application of ALA gel. The precancerous lesions in hamsters were then treated with topical ALA -mediated PDT with light exposure dose of 75 and 100 J/cm2 using LED 635 nm Wonderlight device. It is suggesting that optimization of the given light dose is critical to the success of PDT results.

Paper Details

Date Published: 14 February 2012
PDF: 7 pages
Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240R (14 February 2012); doi: 10.1117/12.907542
Show Author Affiliations
Deng-Fu Yang, Chung Yuan Christian Univ. (Taiwan)
Meng-Ke Tseng, Chung Yuan Christian Univ. (Taiwan)
Chung-Ji Liu, Institute of Oral Biology, National Yang-Ming Univ. (Taiwan)
Taipei Mackay Memorial Hospital (Taiwan)
Nursing and Management College (Taiwan)
Yih-Chih Hsu, Chung Yuan Christian Univ. (Taiwan)

Published in SPIE Proceedings Vol. 8224:
Biophotonics and Immune Responses VII
Wei R. Chen, Editor(s)

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