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Proceedings Paper

Repair of damage and stimulation of growth cone response following laser induced sub-axotomy
Author(s): Tao Wu; Samarendra Mohanty; Jill Miotke; Ronald Meyer; Michael Berns
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Paper Abstract

In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towards the damaged axon. In some cases, the filopodia touch the damaged site. These experiments suggest that guidance cues that are sensed by the growth cones are released from the damaged site. These results also indicate that axon growth cone have a role in repair of the neuronal damage.

Paper Details

Date Published: 9 February 2012
PDF: 7 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820761 (9 February 2012); doi: 10.1117/12.907454
Show Author Affiliations
Tao Wu, Beckman Laser Institute and Medical Clinic (United States)
Samarendra Mohanty, Beckman Laser Institute and Medical Clinic (United States)
The Univ. of Texas at Arlington (United States)
Jill Miotke, Univ. of California, Irvine (United States)
Ronald Meyer, Univ. of California, Irvine (United States)
Michael Berns, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg; Melissa J. Suter; Brian Jet-Fei Wong; Justus F. Ilgner; Stephen Lam; Bodo E. Knudsen; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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