Share Email Print
cover

Proceedings Paper

Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin
Author(s): Jiwei Huang; Jeff S. Xu; Carl Schmidt; Ronald X. Xu
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

We developed a heat-sensitive microbubble (HSM) agent for intraoperative assessment of thermal ablation margins in cancer ablation therapies. The HSM agent, comprising a core of liquid perfluorocarbon (PFC) compound and a shell of biodegradable poly lactic-coglycolic acid (PLGA), was fabricated using an emulsion evaporation method. In our previous study, significant increase of ultrasound contrast was observed after heat activation of HSMs. In this study, intraoperative ultrasonic assessment of thermal ablation margins by HSMs was demonstrated in vivo in a pig model. HSMs were delivered to the pig liver by portal vein injection. Liver ablation was done using a RF ablation probe. Intraoperative ultrasound imaging with HSMs clearly delineated the ablation margin. Fluorescence images of liver tissue samples confirmed the existence and activation of HSMs. This result demonstrated that the HSM agent can be potentially utilized as a multimodal contrast agent for intraoperative ultrasonic and fluorescence assessment of thermal ablation margins in cancer ablation therapies.

Paper Details

Date Published: 14 February 2012
PDF: 8 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 821604 (14 February 2012); doi: 10.1117/12.907110
Show Author Affiliations
Jiwei Huang, The Ohio State Univ. (United States)
Jeff S. Xu, The Ohio State Univ. (United States)
Carl Schmidt, The Ohio State Univ. (United States)
Ronald X. Xu, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

© SPIE. Terms of Use
Back to Top