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Proceedings Paper

A combined time-domain diffuse fluorescence and optical tomography system for breast tumor detection
Author(s): Wei Zhang; Feng Gao; Linhui Wu; Wenjuan Ma; Yiming Lu; Zhongxing Zhou
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Paper Abstract

A combined time-domain diffuse fluorescence and optical tomographic system is proposed based on the multi-channel time-correlated single-photon counting (TCSPC) technique, aiming at enhancing the reliability of breast diffuse optical tomography. The system equipped with two pulsed laser diodes at wavelengths of 780 nm and 830 nm that are specific to the maximal excitation and emission of the FDA-approved ICG dye, and works with a 4-channel TCSPC module to acquire the temporal distributions of the light re-emissions 32 boundary sites of tissues in a tandem serial-to-parallel mode. The performance and efficacy of the system are investigated with phantom experiments for diffuse optical tomography (DOT), as well as fluorescence-guided DOT.

Paper Details

Date Published: 28 February 2012
PDF: 11 pages
Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82141B (28 February 2012); doi: 10.1117/12.907066
Show Author Affiliations
Wei Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Linhui Wu, Tianjin Univ. (China)
Wenjuan Ma, Tianjin Univ. (China)
Yiming Lu, Tianjin Univ. (China)
Zhongxing Zhou, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 8214:
Advanced Biomedical and Clinical Diagnostic Systems X
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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