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Proceedings Paper

Intravital confocal Raman microscopy with multiplexed SERS contrast agents
Author(s): Patrick Z. McVeigh; Brian C. Wilson
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Paper Abstract

Intravital microscopy has been demonstrated to be a powerful technique for studying the delivery of contrast or therapeutic agents to tumours growing in a realistic 3D environment at high resolution. Surface enhanced Raman scattering (SERS)-active nanoparticle contrast agents provide the ability to improve in-vivo detection of tumour tissue through multiplex detection of their uniquely bright spectral lines. However, most work to date has been carried out in-vitro or in ex-vivo tissues. Here we present the results from confocal Raman microscopy in a dorsal skinfold window chamber in mice using SERS-active gold nanoparticle contrast agents directed towards an overexpressed tumour receptor tyrosine kinase.

Paper Details

Date Published: 6 February 2012
PDF: 7 pages
Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340D (6 February 2012); doi: 10.1117/12.907048
Show Author Affiliations
Patrick Z. McVeigh, Univ. of Toronto (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
Univ. Health Network (Canada)

Published in SPIE Proceedings Vol. 8234:
Plasmonics in Biology and Medicine IX
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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