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Proceedings Paper

Fluorescence yield and lifetime tomography from time-resolved transmittances of a breast tumor phantom
Author(s): Yiming Lu; Feng Gao; Wei Zhang; Linhui Wu; Zhongxing Zhou
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Paper Abstract

In optical tumor detection region, there has been recently a considerable interest in simultaneously reconstructing yield and lifetime distributions of fluorescent imaging agents inside a pathologic tissue, since combined monitoring of these two parameters provides a potential means of in vivo interrogating quantitative and environmental information of specific molecules as well as accessing interactions among them. This paper describes the structure of a multi-channel time-correlated single photon counting (TCSPC) system for early breast tumor detection and how we use it to reconstruct the distribution of fluorescent parameters. By using a normalized Born appropriation algorithm, the proposed examination scheme in a transmission mode is experimentally validated to achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with reasonable accuracy. The performance of the instrument will be proved by using two targets be of different fluorescent agents embedded in solid phantom for image reconstruction.

Paper Details

Date Published: 28 February 2012
PDF: 12 pages
Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821419 (28 February 2012); doi: 10.1117/12.907045
Show Author Affiliations
Yiming Lu, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Wei Zhang, Tianjin Univ. (China)
Linhui Wu, Tianjin Univ. (China)
Zhongxing Zhou, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 8214:
Advanced Biomedical and Clinical Diagnostic Systems X
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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