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Proceedings Paper

In vivo photoacoustic imaging of tyrosinase expressing tumours in mice
Author(s): Jan Laufer; Amit Jathoul; Peter Johnson; Edward Zhang; Mark Lythgoe; R. Barbara Pedley; Martin Pule; Paul Beard
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Paper Abstract

Two human tumour cell lines (K562, 293T) were stably transfected to achieve the genetic expression of tyrosinase, which is involved in the production of the pigment eumelanin. The cells were injected subcutaneously into nude mice to form tumour xenografts, which were imaged over a period of up to 26 days using an all-optical photoacoustic imaging system. 3D photoacoustic images of the tumours and the surrounding vasculature were acquired at excitation wavelengths ranging from 600nm to 770nm. The images showed tumour growth and continued tyrosinase expression over the full 26 day duration of the study. These findings were confirmed by histological analysis of excised tumour samples.

Paper Details

Date Published: 23 February 2012
PDF: 5 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230M (23 February 2012); doi: 10.1117/12.907006
Show Author Affiliations
Jan Laufer, Univ. College London (United Kingdom)
Amit Jathoul, Univ. College London (United Kingdom)
Peter Johnson, Univ. College London (United Kingdom)
Edward Zhang, Univ. College London (United Kingdom)
Mark Lythgoe, Univ. College London (United Kingdom)
R. Barbara Pedley, Univ. College London (United Kingdom)
Martin Pule, Univ. College London (United Kingdom)
Paul Beard, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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